CBD and Addiction
CBD reduces cigarette consumption in tobacco smokers
The endocannabinoid role system in the addiction of nicotine is gaining acknowledgment. There was a conduction of a pilot study that was aimed at assessing the effect of CBD usage for those smokers that wished to quit smoking. 24 smokers were given CBD inhalers when they felt like smoking. In that same treatment week, the placebo-treated smokers showed no change of the number of cigarettes smoked by the affected, while the CBD treated smokers showed a significant change as they were able to reduce the smoking number of people by 40%. These data hence show that CBD is a perfect treatment for the people that have a nicotine addiction.
Inhibition of monoacylglycerol lipase reduces nicotine withdrawal
The sudden discontinuation of nicotine does induce a withdrawal syndrome in the animals that do depend on nicotine, being inconsistent with somatic and signs that are effective, avoiding it leads to the maintenance of drugs. While the fatty acids blockade exacerbates responses of withdrawal in the mice that depend on nicotine, the monoacylglycerol lipase role in the withdrawal of nicotine is still unexplored. Therefore, this study suggests that inhibition of MAGL may be a target for treating nicotine dependence.
CBD inhibits the reward facilitating morphine effect
Cannabidiol induces the rodent’s central system. It has its effects on the stimulation of the brain reward and the facilitating of reward effects of the abuses of drugs has not been examined yet. The findings show that the cannabidiol does not remove the property of reinforcement in the paradigm of ICSS at any of the tested doses. The effects were mediated by dorsal raphe receptors. This result does suggest that interferences of Cannabidiol with the brain mechanisms of reward that are responsible for the expressing of properties of acute reinforcement thus showing that it may be used clinically in attenuating the rewarding effects of opioids.
Differential cannabinol effects and cannabidiol on THC induced responses during the abstinence in the rats’ that depend on morphine.
The same cannabinol dose (CBN) or CBD further raised the precipitated abstinence attenuation sign which were observed in the rats that depend on morphine which were also given an acute delta dose. Contrasting, behavior of rotational behavior that is usually observed in THC rats that have undergone treatment during the absence of morphine was not raised by the CBN but the CBD potentiated it. These data gives an illustration of the differences that exist between Cannabinoids while they are interacting with the Delta 9 THC which can be so relevant to the available clinical usage of cannabis.
Impact of Cannabis during stabilization on methadone maintenance treatment
The cannabis objective rates were high when there was an induction of methadone, drastically dropping by following the stabilization of the dose. The cannabis use history correlated with its usage during the MMT however, it did not have a negative impact on the induction process of the methadone. The data of the pilot also gave a suggestion that opiate withdrawal objective ratings lessen in the patients of MMT by the use of cannabis during the stabilization process. These findings may touch on the intervention of the novel to be employed during the treatment of opiate dependency which mostly aims at the system interactions of the cannabinoid opioid.
Medical cannabis laws and opioid analgesic overdose mortality in the United States
The overdose of opioid analgesic mortality still continues to increase in the United States of America; this is facilitated by the increased chronic pain prescribers. Due to the fact that chronic pain being main medical cannabis induction, the laws that give them access to the cannabis of medicine may interfere with overdose to the opioid analgesics in those states that have accepted to enact them. The objective of this study is to try and determine the association that exists between the state medical presence laws and mortality of the opioid analgesic. The results were that three of the states inclusive of California had these laws of medical cannabis in use. The other ten states inclusive of Alaska put in use these laws of medicine in the year1999-2010, those states that have this law had a 24% lower opioid rate compared with those states without the laws of medical cannabis associates themselves with a slightly lower level of state opioid overdose rates of mortality. An enhanced investigation is needed to give a determination of how the laws of medical cannabis can interact with those policies that are aimed to prevent the overdose of the opioid analgesic.
CBD for the cannabis withdrawal treatment
The cannabis withdrawal in the addictive users is usually followed by the increase of anxiety, appetite loss, and irritability alongside with restlessness. The tolerate cannabis together with cannabis withdrawal symptoms are interpreted to be the CB1 receptors results. Its case summary shows that there is a woman aged 19 years who was diagnosed with cannabis withdrawal symptoms and got the treatments of the CBD for 10 consecutive days. The symptom assessments of a daily basis showed the sign that the significant withdrawal was no more, also symptoms like anxiety and dissociative lacked when the girl received this treatment such a positive sign and cure from the CBD. The CBD can be used when treating any individual that has problems to do with the Cannabis withdrawal syndrome.
CLINICAL STUDY RESOURCES:
- CBD inhibits the reward-facilitating effect of morphine
- CBD for the treatment of cannabis withdrawal syndrome
- CBD as an Intervention for Addictive Behaviors
- CBD reduces cigarette consumption in tobacco smokers
- Inhibition of monoacylglycerol lipase enzyme reduces nicotine withdrawal
- Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances
- Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats
- Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment
- Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010
- Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
- CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
- Early Phase in the Development of CBD as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage
- Epigenetic mechanisms associated with addiction-related behavioural effects of nicotine and/or cocaine: implication of the endocannabinoid system
- Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents